S100A8/A9 and S100A9 reduce acute lung injury

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S100A8/A9 and S100A9 reduce acute lung injury

S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic comparison of their effects in vivo are limited. Here we assess inflammation in mur...

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ژورنال

عنوان ژورنال: Immunology & Cell Biology

سال: 2017

ISSN: 0818-9641,1440-1711

DOI: 10.1038/icb.2017.2